My primary interests with 3D printing are for expressing organic forms.
I have been working with meshes in blender for most of my models,
but I also use TinkerCAD for simpler parts.
This is a fairly decent sized printer which I built myself.
I highly recommend it as a project! The controller is a RAMPS board,
and the firmware is Marlin from the RepRap project. it all works beautifully.